1、细胞自噬为核心的医药用纳米材料的生物学效应研究
2、纳米细胞毒理学
3、基于生物学效应研究的医药用纳米材料改进策略

1、合肥工业大学人才引进科研启动资金
2、国家自然科学基金 青年项目：几种无机医药纳米材料对自噬性溶酶体再生的影响研究 （编号31600813）（2017-2019）项目负责人
3、国家重大科学研究计划：纳米材料调控自噬的机制、安全性及在肿瘤诊疗中的应用研究（编号2013CB933900）（2013-2017）学术骨干

代表性论文

[1] J.-Q. Zhang#, W. Zhou#*, S.-S. Zhu, J. Lin, P.-F. Wei, F.-F. Li, P.-P. Jin, H. Yao, Y.-J. Zhang, Y. Hu, Y.-M. Liu, M. Chen, Z.-Q. Li, X. Liu, L. Bai, L. Wen*. Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes. Small 2016, DOI 10.1002/smll.201602876.

[2] J. Zhang, W. Zhou*, J. Lin, P. Wei, Y. Zhang, P. Jin, M. Chen, N. Man, L. Wen*. Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy. The International Journal of Biochemistry & Cell Biology 2016, 70, 76.

[3] J. Lin, S. Shi, J. Zhang, Y. Zhang, L. Zhang, Y. Liu, P. Jin, P. Wei, R. Shi, W. Zhou*, L. Wen*. Giant Cellular Vacuoles Induced by Rare Earth Oxide Nanoparticles are Abnormally Enlarged Endo/Lysosomes and Promote mTOR-Dependent TFEB Nucleus Translocation. Small 2016, 12, 5759.

[4] P. Jin, F. Li, R. Ruan, L. Zhang, N. Man, Y. Hu, W. Zhou*, L. Wen*. Enhanced Transdermal Delivery of Epidermal Growth Factor Facilitated by Dual Peptide Chaperone Motifs. Protein and Peptide Letters 2014, 21, 550.

[5] W. Zhou#, Y. Miao, Y. Zhang, L. Liu, J. Lin, J. Y. Yang, Y. Xie, L. Wen*. Induction of cyto-protective autophagy by paramontroseite VO2 nanocrystals. Nanotechnology 2013, 24, 165102.

[6] Ma, Yan ; Chen, Huajian; Hao Baimei; Zhou Junhong; He Gang; Miao Zhaohua *; Xu Yan; Gao Li; Zhou Wei*; Zha Zhengbao*, A chloroquine-loaded Prussian blue platform with controllable autophagy inhibition for enhanced photothermal therapy, Journal of Materials Chemistry B, 2018.10.7, 6(37)：5854~5859.

[7] Benjin Chen, Yifei Jiang, Mengli Zhao, Wanni Wang, Zhaoyou Chu, Ronghua Huo, Fan Hu, Wei Zhou*, Tao He*, Haisheng Qian*, Ag nanoparticles decorated hybrid microspheres for superior antibacterial properties,Materials Letters,Volume 262,2020,127057

[8] Hao BM, Liu YN, Zhang CY, Li GQ, Wang WN, Xu WD, Zha ZB, Wang F, Li C, Miao ZH, Yang XX, Chen YL, Qian HS, Zhou W. Autophagic blockage by bismuth sulfide nanoparticles inhibits migration and invasion of HepG2 cells. Nanotechnology. 2020 Nov 13;31(46):465102.