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- 姓名：王峰
- 职务：
- 职称：教授、博导
- 所属系：药物科学与工程系
- 邮箱：fengw420@hfut.edu.cn ；fengw420@gmail.com
- 办公地点：

个人简介
研究领域
科研项目
学术成果
荣誉奖项

王峰博士2007年毕业于合肥工业大学，获得学士学位；

2012年毕业于中国科学技术大学合肥微尺度物质科学国家实验室（筹），获得博士学位，导师为王均教授。

博士毕业后在加拿大滑铁卢大学（University of Waterloo，2012.11-2016.1，2016.4-2016.10）化学系及纳米技术研究所从事博士后研究，导师；

王峰博士近年来一直致力于利用分析化学的手段研究纳米-生物界面的工作，在纳米材料与脂质体、细胞膜、核酸、免疫屏障的相互作用等领域取得了丰硕的研究成果。迄今，已在国际学术期刊J. Am. Chem. Soc.，Angew.Chem. Int. Ed.，Adv. Mater.，Nano Lett.，ACS Nano，Small，Biomaterials，Chem. Commun.，Nanoscale，Anal. Chem.等发表55篇学术论文。其中，以第一、共同第一和通讯作者身份在J. Am. Chem. Soc.（1篇），Angew. Chem. Int. Ed.（1篇），Adv. Mater.（2篇），ACS Nano（3篇）等国际期刊上发表31篇学术论文。研究工作开始受到国内外同行专家的关注，迄今所有论文共被他引3400余次，6篇论文他引超过100次（单篇最高他引次755）。目前承担基金包括国家自然科学基金面上项目两项、国家自然科学基金青年基金一项、安徽省自然基金等。

主要研究方向集中在纳米-生物界面，包括：
（1）纳米材料与细胞膜相互作用的调控及其在药物（基因）传递中的应用；
（2）高效低毒抗肿瘤纳米药物的研制及其作用机制的研究；
（3）纳米材料的毒理学评价；
（4）纳米技术在现代农业中的应用。

1.国家自然科学基金“面上项目”，亲水头部反转脂质与生物-纳米界面作用过程的机制、调控及生物医学应用，31971314，2020年1月～2023年12月，主持
2.国家自然科学基金“面上项目”，纳米材料对脂质体相行为和流动性影响的基础研究，31571023，2016年1月～2019年12月，主持
3.国家自然科学基金“青年科学基金项目”，DNA在脂质体、纳米金表面杂交动力学的研究及生物应用，81501587，2016年1月～2018年12月，主持
4.安徽省重点研究与开发计划国际科技合作专项，基于多模态影像的新型脂质体制剂在实体瘤EPR效应中的研究，202104b11020015，2021年1月～2023年12月，主持
5.安徽省自然科学基金“杰青项目”，2018年7月～2021年6月，主持

[31] Z. F. Wang,♯ Y. Yan,♯ C. Li,♯ Y. Yu, S. Cheng, S. Chen, X. J. Zhu, L. P. Sun, W. Tao, J. W. Liu, F. Wang*, Fluidity-guided assembly of Au@Pt on liposomes as a catalase-powered nanomotor for effective cell uptake in cancer cells and plant leaves, ACS Nano, 2022, accept.

[30] Y. Yu♯, Z. F. Wang♯, S. C. Wu, C. M. Zhu, X. S. Meng, C. Li, S. Cheng, W. Tao, F. Wang*, A glutathione-sensitive nanoglue platform with effective nucleic acids gluing onto liposomes for photo-gene therapy. ACS Applied Materials & Interfaces, 2022, 14, 25126-25134.

[29] L. P. Sun♯, Y. Yan♯, S. Chen, Z. J. Zhou, W. Tao, C. Li*, Y. Feng*, F. Wang*, Co-N-C single-atom nanozymes with oxidase-like activity for highly sensitive detection of biothiols. Analytical and Bioanalytical Chemistry, 2022, 414, 1857-1865.

[28] Y. Yan♯, X. Zhu♯, Y. Yu♯, C. Li, Z. Zhang*, F. Wang*, Nanotechnology strategies for plant genetic engineering. Advanced Materials, 2022, 34, 2106945.

[27] S. Chen♯, Y. Yan♯, Y. Yu♯, Z. F. Wang, X. J. Zhu, L. P. Sun, C. Li, F. Wang*, Ferric ions as a catalytic mediator in metal-EGCG network for bactericidal effect and pathogenic biofilm eradication at physiological pH. Advanced Materials Interfaces, 2021, 8, 2101605.

[26] L. P. Sun♯, C. Li♯, Y. Yan, Y. Yu, H. Zhao, Z.J. Zhou, F. Wang*, Y. Feng*, Engineering DNA/Fe-N-C single-atom nanozymes interface for colorimetric biosensing of cancer cells. Analytica Chimica Acta, 2021, 1180, 338856.

[25] P. P. Deng♯, Y. Y. Pei♯, M. L. Liu, W. Z. Song, M. R. Wang, F. Wang*, C. X. Wu, L. Xu*, A rapid “on-off-on” mitochondria-targeted phosphorescent probe for selective and consecutive detection of Cu2+ and cysteine in live cells and zebrafish. RSC Advances, 2021, 11, 7610-7620.

[24] H. Li♯, M. L. Li♯, Y. C. Yang, F. Wang, F. Wang*, C. Li*, Aptamer-Linked CRISPRCas12a-Based Immunoassay. Analytical Chemistry, 2021, 93, 3209-3216.

[23] J. Y. Huang♯, M. Jian♯, S. H. Chen♯, S. Y. Zhang, T. Liu*, C. Li*, F. Wang*, A soft metal-polyphenol capsule-based ultrasensitive immunoassay for electrochemical detection of Epstein-Barr (EB) virus infection. Biosensors and Bioelectronics, 2020, 143, 112310.

[22] Y. C. Ma♯, Y. X. Zhang♯, X. Q. Li♯, Y. Y. Zhao, M. Li, W. Jiang, X. F. Tang, J. X. Dou, L. G. Lu, F. Wang*, Y. C. Wang*, Near-infrared II phototherapy induces deep tissue immunogenic cell death and potentiates cancer immunotherapy. ACS Nano, 2019, 13, 11967-11980.

[21] H. Wang, H. Li, Y. Huang, M. H. Xiong, F. Wang*, C. Li*, A label-free electrochemical biosensor for highly sensitive detection of gliotoxin based on DNA nanostructure/MXene nanocomplexes. Biosensors and Bioelectronics, 2019, 142, 111531.

[20] X. S. Wang, X. Q. Li, H. Wang, X. H. Zhang, L. Zhang, F. Wang*, J. W. Liu*, Charge and coordination directed liposome fusion onto SiO2 and TiO2 nanoparticles. Langmuir, 2019, 35, 1672-1681.

[19] X. R. Liu, X. Q. Li, W. Xu, X. H. Zhang, Z. C. Huang, F. Wang*, J. W. Liu*, Sub-angstrom gold nanoparticle/liposome interfaces controlled by halides. Langmuir, 2018, 34, 6628-6635.

[18] Y. B. Li, F. Wang*, J. Liu*, Headgroup inversed liposomes: biointerfaces, supported bilayers and applications. Langmuir, 2018, 34, 9337-9348.

[17] S. Y. Li, F. Wang*, X. Q. Li, J. Chen, X. H. Zhang, Y. C. Wang*, J. W. Liu*, Dipole Orientation matters: Longer-circulating choline phosphate than phosphocholine liposomes for enhanced tumor targeting. ACS Applied Materials & Interfaces, 2017, 9, 17736-17744.

[16] F. Wang, X. H. Zhang, Y. B. Liu, Z. Y. Lin, B. W. Liu, J. W. Liu*, Profiling metal oxides with lipids: Magnetic liposomal nanoparticles displaying DNA and proteins. Angewandte Chemie International Edition, 2016, 55, 12063-12067.

[15] F. Wang, D. Curry, J. W. Liu*, Driving adsorbed gold nanoparticle assembly by merging lipid gel/fluid interfaces. Langmuir, 2015, 31, 13271-13274.

[14] F. Wang, J. W. Liu*, A stable lipid/TiO2 interface with headgroup inversed phosphocholine and a comparison with SiO2. Journal of the American Chemical Society, 2015, 137, 11736-11742.

[13] F. Wang, J. W. Liu*, Self-healable and reversible liposome leakage by citrate-capped gold nanoparticles probing initial adsorption/desorption induced lipid phase transition. Nanoscale, 2015, 7, 15599-15604.

[12] F. Wang, J. W. Liu*, Evaporation induced wrinkling of graphene oxide at the nanoparticle interface. Nanoscale, 2015, 7, 919-923.

[11] F. Wang, J. W. Liu*, Liposome supported metal oxide nanoparticles: interaction mechanism, light controlled content release and intracellular delivery. Small, 2014, 10, 3927-3931.

[10] F. Wang, J. W. Liu*, Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with graphene oxide. Nanoscale, 2014, 6, 7079-7084.

[9] F. Wang, B. W. Liu, P. J. J. Huang, J. W. Liu*, Rationally designed nucleobase and nucleotide coordinated nanoparticles for selective DNA adsorption and detection. Analytical Chemistry, 2013, 85, 12144-12151.

[8] F. Wang, B. W. Liu, A. C. F. Ip, J. W. Liu*, Orthogonal adsorption onto nano-graphene oxide using different intermolecular forces for multiplexed delivery. Advanced Materials, 2013, 25, 4087-4092.

[7] F. Wang, P. J. J. Huang, J. W. Liu*, Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine. Chemical Communications, 2013, 49, 9482-9484.

[6] F. Wang, J. W. Liu*, Nanodiamond decorated liposomes as highly biocompatible delivery vehicles and a comparison with carbon nanotube and graphene oxide. Nanoscale, 2013, 5, 12375-12382.

[5] W. Q. Li♯, F. Wang♯, Z. M. Liu, Y. C. Wang, J. Wang*, F. Sun*, Gold nanoparticles elevate plasma testosterone levels in male mice without affecting fertility. Small, 2013, 9, 1708-1714.

[4] F. Wang♯, Y. C. Wang♯, S. Dou, M. H. Xiong, T. M. Sun, J. Wang*, Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano, 2011, 5, 3679-3692.

[3] F. Wang♯, R. Saran♯, J. W. Liu*, Tandem DNAzymes for mRNA cleavage: choice of enzyme, metal ions and the antisense effect. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 1460-1463.

[2] Y. C. Wang♯, F. Wang♯, T. M. Sun, J. Wang*, Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjugate Chemistry, 2011, 22, 1939-1945.

[1] F. Wang, Y. C. Wang, L. F. Yan, J. Wang*, Biodegradable vesicular nanocarriers based on poly(ε-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery. Polymer, 2009, 50, 5048-5054.

1.安徽省平台引进奖补项目（2016）
2.安徽省自然科学基金“杰青项目”（2018）
3.美国通用电器（GE）基金会科技创新一等奖（2011）

职务：		职称：	教授、博导
所属系：	药物科学与工程系	邮箱：	fengw420@hfut.edu.cn ；fengw420@gmail.com
办公地点：		学术成果	[31] Z. F. Wang,♯ Y. Yan,♯ C. Li,♯ Y. Yu, S. Cheng, S. Chen, X. J. Zhu, L. P. Sun, W. Tao, J. W. Liu, F. Wang, Fluidity-guided assembly of Au@Pt on liposomes as a catalase-powered nanomotor for effective cell uptake in cancer cells and plant leaves, ACS Nano, 2022, accept. [30] Y. Yu♯, Z. F. Wang♯, S. C. Wu, C. M. Zhu, X. S. Meng, C. Li, S. Cheng, W. Tao, F. Wang, A glutathione-sensitive nanoglue platform with effective nucleic acids gluing onto liposomes for photo-gene therapy. ACS Applied Materials & Interfaces, 2022, 14, 25126-25134. [29] L. P. Sun♯, Y. Yan♯, S. Chen, Z. J. Zhou, W. Tao, C. Li, Y. Feng, F. Wang, Co-N-C single-atom nanozymes with oxidase-like activity for highly sensitive detection of biothiols. Analytical and Bioanalytical Chemistry, 2022, 414, 1857-1865. [28] Y. Yan♯, X. Zhu♯, Y. Yu♯, C. Li, Z. Zhang, F. Wang, Nanotechnology strategies for plant genetic engineering. Advanced Materials, 2022, 34, 2106945. [27] S. Chen♯, Y. Yan♯, Y. Yu♯, Z. F. Wang, X. J. Zhu, L. P. Sun, C. Li, F. Wang, Ferric ions as a catalytic mediator in metal-EGCG network for bactericidal effect and pathogenic biofilm eradication at physiological pH. Advanced Materials Interfaces, 2021, 8, 2101605. [26] L. P. Sun♯, C. Li♯, Y. Yan, Y. Yu, H. Zhao, Z.J. Zhou, F. Wang, Y. Feng, Engineering DNA/Fe-N-C single-atom nanozymes interface for colorimetric biosensing of cancer cells. Analytica Chimica Acta, 2021, 1180, 338856. [25] P. P. Deng♯, Y. Y. Pei♯, M. L. Liu, W. Z. Song, M. R. Wang, F. Wang, C. X. Wu, L. Xu, A rapid “on-off-on” mitochondria-targeted phosphorescent probe for selective and consecutive detection of Cu2+ and cysteine in live cells and zebrafish. RSC Advances, 2021, 11, 7610-7620. [24] H. Li♯, M. L. Li♯, Y. C. Yang, F. Wang, F. Wang, C. Li, Aptamer-Linked CRISPRCas12a-Based Immunoassay. Analytical Chemistry, 2021, 93, 3209-3216. [23] J. Y. Huang♯, M. Jian♯, S. H. Chen♯, S. Y. Zhang, T. Liu, C. Li, F. Wang, A soft metal-polyphenol capsule-based ultrasensitive immunoassay for electrochemical detection of Epstein-Barr (EB) virus infection. Biosensors and Bioelectronics, 2020, 143, 112310. [22] Y. C. Ma♯, Y. X. Zhang♯, X. Q. Li♯, Y. Y. Zhao, M. Li, W. Jiang, X. F. Tang, J. X. Dou, L. G. Lu, F. Wang, Y. C. Wang, Near-infrared II phototherapy induces deep tissue immunogenic cell death and potentiates cancer immunotherapy. ACS Nano, 2019, 13, 11967-11980. [21] H. Wang, H. Li, Y. Huang, M. H. Xiong, F. Wang, C. Li, A label-free electrochemical biosensor for highly sensitive detection of gliotoxin based on DNA nanostructure/MXene nanocomplexes. Biosensors and Bioelectronics, 2019, 142, 111531. [20] X. S. Wang, X. Q. Li, H. Wang, X. H. Zhang, L. Zhang, F. Wang, J. W. Liu, Charge and coordination directed liposome fusion onto SiO2 and TiO2 nanoparticles. Langmuir, 2019, 35, 1672-1681. [19] X. R. Liu, X. Q. Li, W. Xu, X. H. Zhang, Z. C. Huang, F. Wang, J. W. Liu, Sub-angstrom gold nanoparticle/liposome interfaces controlled by halides. Langmuir, 2018, 34, 6628-6635. [18] Y. B. Li, F. Wang, J. Liu, Headgroup inversed liposomes: biointerfaces, supported bilayers and applications. Langmuir, 2018, 34, 9337-9348. [17] S. Y. Li, F. Wang, X. Q. Li, J. Chen, X. H. Zhang, Y. C. Wang, J. W. Liu, Dipole Orientation matters: Longer-circulating choline phosphate than phosphocholine liposomes for enhanced tumor targeting. ACS Applied Materials & Interfaces, 2017, 9, 17736-17744. [16] F. Wang, X. H. Zhang, Y. B. Liu, Z. Y. Lin, B. W. Liu, J. W. Liu, Profiling metal oxides with lipids: Magnetic liposomal nanoparticles displaying DNA and proteins. Angewandte Chemie International Edition, 2016, 55, 12063-12067. [15] F. Wang, D. Curry, J. W. Liu, Driving adsorbed gold nanoparticle assembly by merging lipid gel/fluid interfaces. Langmuir, 2015, 31, 13271-13274. [14] F. Wang, J. W. Liu, A stable lipid/TiO2 interface with headgroup inversed phosphocholine and a comparison with SiO2. Journal of the American Chemical Society, 2015, 137, 11736-11742. [13] F. Wang, J. W. Liu, Self-healable and reversible liposome leakage by citrate-capped gold nanoparticles probing initial adsorption/desorption induced lipid phase transition. Nanoscale, 2015, 7, 15599-15604. [12] F. Wang, J. W. Liu, Evaporation induced wrinkling of graphene oxide at the nanoparticle interface. Nanoscale, 2015, 7, 919-923. [11] F. Wang, J. W. Liu, Liposome supported metal oxide nanoparticles: interaction mechanism, light controlled content release and intracellular delivery. Small, 2014, 10, 3927-3931. [10] F. Wang, J. W. Liu, Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with graphene oxide. Nanoscale, 2014, 6, 7079-7084. [9] F. Wang, B. W. Liu, P. J. J. Huang, J. W. Liu, Rationally designed nucleobase and nucleotide coordinated nanoparticles for selective DNA adsorption and detection. Analytical Chemistry, 2013, 85, 12144-12151. [8] F. Wang, B. W. Liu, A. C. F. Ip, J. W. Liu, Orthogonal adsorption onto nano-graphene oxide using different intermolecular forces for multiplexed delivery. Advanced Materials, 2013, 25, 4087-4092. [7] F. Wang, P. J. J. Huang, J. W. Liu, Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine. Chemical Communications, 2013, 49, 9482-9484. [6] F. Wang, J. W. Liu, Nanodiamond decorated liposomes as highly biocompatible delivery vehicles and a comparison with carbon nanotube and graphene oxide. Nanoscale, 2013, 5, 12375-12382. [5] W. Q. Li♯, F. Wang♯, Z. M. Liu, Y. C. Wang, J. Wang, F. Sun, Gold nanoparticles elevate plasma testosterone levels in male mice without affecting fertility. Small, 2013, 9, 1708-1714. [4] F. Wang♯, Y. C. Wang♯, S. Dou, M. H. Xiong, T. M. Sun, J. Wang, Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano, 2011, 5, 3679-3692. [3] F. Wang♯, R. Saran♯, J. W. Liu, Tandem DNAzymes for mRNA cleavage: choice of enzyme, metal ions and the antisense effect. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 1460-1463. [2] Y. C. Wang♯, F. Wang♯, T. M. Sun, J. Wang, Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjugate Chemistry, 2011, 22, 1939-1945. [1] F. Wang, Y. C. Wang, L. F. Yan, J. Wang*, Biodegradable vesicular nanocarriers based on poly(ε-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery. Polymer, 2009, 50, 5048-5054.
研究领域	主要研究方向集中在纳米-生物界面，包括：（1）纳米材料与细胞膜相互作用的调控及其在药物（基因）传递中的应用；（2）高效低毒抗肿瘤纳米药物的研制及其作用机制的研究；（3）纳米材料的毒理学评价；（4）纳米技术在现代农业中的应用。	科研项目	1.国家自然科学基金“面上项目”，亲水头部反转脂质与生物-纳米界面作用过程的机制、调控及生物医学应用，31971314，2020年1月～2023年12月，主持 2.国家自然科学基金“面上项目”，纳米材料对脂质体相行为和流动性影响的基础研究，31571023，2016年1月～2019年12月，主持 3.国家自然科学基金“青年科学基金项目”，DNA在脂质体、纳米金表面杂交动力学的研究及生物应用，81501587，2016年1月～2018年12月，主持 4.安徽省重点研究与开发计划国际科技合作专项，基于多模态影像的新型脂质体制剂在实体瘤EPR效应中的研究，202104b11020015，2021年1月～2023年12月，主持 5.安徽省自然科学基金“杰青项目”，2018年7月～2021年6月，主持
荣誉奖项	1.安徽省平台引进奖补项目（2016） 2.安徽省自然科学基金“杰青项目”（2018） 3.美国通用电器（GE）基金会科技创新一等奖（2011）